Leishmania donovani Suppresses Activated Protein 1 and NF- B Activation in Host Macrophages via Ceramide Generation: Involvement of Extracellular Signal-Regulated Kinase
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چکیده
Leishmania donovani Suppresses Activated Protein 1 and NFB Activation in Host Macrophages via Ceramide Generation: Involvement of Extracellular Signal-Regulated Kinase Sanjukta Ghosh, Sandip Bhattacharyya, Madhumita Sirkar, Gouri Shankar Sa, Tanya Das, Debashis Majumdar, Syamal Roy, and Subrata Majumdar* Department of Microbiology and Department of Animal Physiology, Bose Institute, Calcutta 700 054, and Indian Institute of Chemical Biology, Calcutta 700 032, India
منابع مشابه
Leishmania donovani suppresses activated protein 1 and NF-kappaB activation in host macrophages via ceramide generation: involvement of extracellular signal-regulated kinase.
In vitro infection of murine peritoneal macrophages with the protozoan Leishmania donovani has been found to alter the signaling parameters of the host. The present study indicates that the enhancement of intracellular ceramide level in macrophages after infection is a major event relating to macrophage dysfunction. We have previously demonstrated that increased ceramide synthesis in host macro...
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In order to survive within the macrophages of its host organism, the protozoan parasite Leishmania inhibits a number of critical, gamma interferon (IFN-gamma)-inducible, macrophage functions, including the generation of nitric oxide. We have previously shown that the protein tyrosine phosphatase SHP-1 (Src-homology 2 domain containing phosphatase-1) is activated during Leishmania infection and ...
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